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Created for publication in the Lancet, this illustration explains the molecular mechanisms of action in penile erection in relation to erectile dysfunction.

PDE5 inhibitors (for example, Viagra, Cialis, and Levitra) are drugs used for treating erectile dysfunction. These drugs block the action of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells of the blood vessels thereby slowing the relaxation of the smooth muscle and the subsequent relaxation of the penis.

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